Yang institute of health, chinese academy of medical sciences, beijing, peoples republic of china keshan disease is an endemic cardiomyopathy which was first observed in keshan county, heilonjiang province, northeast china. Keshan disease is characterized by heart failure, cardiac enlargement, abnormalities of ekg, and cardiogenic shock. Selenium is part of a nutritional antioxidant system that protects cell membranes and structural membranes from lipid peroxidation. Selenium deficiency and keshan disease 321 figure 1. Pdf comparing gene expression profiles of kashinbeck. Important facts about parenteral adolescents selenium trace. Pubmed is a searchable database of medical literature and lists journal articles that discuss keshan disease. Request pdf keshan disease, selenium deficiency, and the selenoproteome investigation of a muscle disease in animals and a cluster of cases of. Selenium is an essential mineral required by the body. Nutritional diseases genetic and rare diseases information. Despite the strong evidence that selenium deficiency is a fundamental factor in keshans disease, it is seasonal and the cause is a virus that produces inflammation of the heart. Keshan disease keshan disease is a reversible endemic cardiomyopathy, characterized by focal myocardial necrosis associated with inflammatory infiltrates and calcification, which can lead to acute or chronic episodes of cardiogenic shock and congestive heart failure 32.
It is named for the northeastern chinese county keshan, where the disease prevalence is high because of seleniumdeficient soil. Keshan disease is a potentially fatal disease of the heart. The type of mass wasting in which a house may move with the least damage is. For language access assistance, contact the ncats public information officer. What links here related changes upload file special pages permanent link page. In addition to a low selenium intake, low blood and hair selenium concentrations are associated with keshan disease. Kashinbeck disease expanding the spectrum of iodinedeficiency disorders selenium, as selenocysteine, is an integral component of two important enzymes glutathione peroxidase and iodothyronine deiodinase that are present in many tissues, including the thyroid gland. The heart disorder that is caused by selenium deficiency is keshan disease.
Selenium, epidemiology, keshan disease, kashinbeck disease. Loss of heart tissue if keshans disease is not diagnosed and treated, then it can result in heart failure due to the selenium deficiency. There are ways to prevent keshans disease from occurring. The role of selenium in keshan disease springerlink. Keshan disease is a congestive cardiomyopathy probably caused by dietary deficiency of selenium, named after keshan, where symptoms were first noted. The disease peaked in 19601970, claiming thousands of lives. Nutritional factors that may be protective against cancer include. Genetic disease causes severe skin problems due to defect in zinc. From 1984 to 1986, a national comprehensive scientific investigation on kd in chuxiong region of yunnan province in the southwest china was conducted.
It was first observed in keshan province in china, and it has since been found in other areas where the selenium level in the soil is low. Keshan disease definition of keshan disease by medical. Institute of health, chinese academy of medical sciences. Symptoms of keshans disease health conditions vital. Keshan disease herbal treatment, prevention, symptoms, causes. Keshan disease kd is a dilated cardiomyopathy closely related with a diet deficient in the mineral selenium. National laboratory of biomacromolecules, institute of biophysics, chinese academy of sciences, beijing 100101, china.
Keshan heart disease university of medicine and dentistry. There are ways to prevent keshan s disease from occurring. Gbt 170192010 control criteria for keshan disease areas. He was also suffering from frequent attacks of cough and cold since 6 months of age which was marked prior to admission. Enteroviruses and in particular coxsackieviruses were isolated from keshan disease victims 8.
Keshan disease uncountable a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of coxsackievirus. In addition, an individual can experience eczema, arthritis, cataracts and infections. Keshan disease is a cardiomyopathy endemic in children and pregnant women who live in the keshan region of china, where selenium levels in food are extremely low chen et al. Selenium south tees hospitals nhs foundation trust. It has also been suggested that keshans disease may be, at least partly due to infection by a virus coxsackievirus b3 cvb30, which. Recently, using rtpcr techniques, archived heart tissues from keshan. Keshan disease kd is a potentially fatal form of cardiomyopathy disease of the heart muscle endemic in certain areas of china. In the disease prevention category, there are healthlinkbc file topics about animal and insect borne diseases, food and water borne diseases, infectious diseases, diseases related to travel, as well as immunizations available in british columbia to protect against disease. Important facts about parenteral adolescents selenium. While individuals who are diagnosed with a selenium deficiency and receive selenium supplements have been able to see some improvement in the continuing development of the disease, however, it can not reserve any of the heart muscle damage that has already occurred. Almost certainly, gross deficiencies of these trace elements hardly ever occur. Kashinbeck disease kbd is a chronic, endemic type of osteochondropathy disease of the bone that is mainly distributed from northeastern to southwestern china, including 15 provinces.
Keshan disease can lead to higher rates of cancer, cardiovascular disease and strokes. The infant had fair complexion, sparse fuzzy wooly hair with marked trunkal hypotonia. These symptoms were later found prevalent in a wide belt extending from northeast to southwest china, all due to selenium. As one of several types of nutritional diseases, keshan disease is unique in that it. Here, we used stepwise multiple regression analysis to analyze the risk factors of the disease and the main. Three specific diseases have been associated with selenium deficiency.
These symptoms were later found prevalent in a wide belt extending from northeast to. To research the causes of keshan disease, consider researching the causes of these these diseases that may be similar, or associated with keshan disease. Keshan zhang, huanan liu haixue zheng lanzhou veterinary. Named after keshan county of heilongjiang province, northeast china, where symptoms were first noted. It is hard to consider keshan disease preventable because the only way to ensure that the individual is getting enough selenium would be to test the soil in the area. Total rna was isolated from peripheral blood mononuclear cells. Keshan disease kd is a lifethreatening condition that affects the heart muscle. It was later found to be prevalent in a wide belt extending from southwest to northeast china. Section a questions 120 use the terms provided below to fill in the 20 blank spaces in the statements that follow.
Keshan disease is an endemic cardiomyopathy associated with selenium deficiency in china. The incidence of the disease was dramatically reduced after the population was supplemented with sodium selenite. Gbt 170192010 control criteria for keshan disease areas text of document is in chinese available for subscriptions. It was first noted in the keshan province in heilongjiang, china.
If you have problems viewing pdf files, download the latest version of adobe reader. Keshan disease is a disease of heart muscle congestive cardiomyopathy which is potentially fatal. Keshan disease, which results in an enlarged heart and poor heart function, occurs in selenium deficient children. There is evidence that selenium deficiency may contribute to development of a form of heart disease, hypothyroidism, and a weakened immune system. Eat foods rich in selenium people who ensure they have a diet that includes foods rich in selenium have protection against developing keshans disease and have very little risk for this condition. Kashinbeck disease expanding the spectrum of iodine. If keshans disease is not diagnosed and treated, then it can result in heart failure due to the selenium deficiency. Quick guide to cdbg eligible activities to support. A collection of disease information resources and questions answered by our genetic and rare diseases information specialists for keshan disease.
Advertisement it has also been suggested that keshans disease may be, at least partly due to infection by a virus coxsackievirus b3 cvb30, which would initially present with the typical viral infection symptoms such as. Keshan disease is a potentially fatal form of cardiomyopathy disease of the heart muscle. Ecg changes of an acute case of keshan disease patient figure 2. These symptoms were later found prevalent in a wide belt extending from northeast to southwest china, all due to seleniumdeficient soil. Selenium supplements has been found to protect people from developing keshan disease but cannot reverse heart muscle damage once it occurs. The prevalence of keshan disease in china international journal. One of the most important measures to control and prevent fmd is the vaccine and immunity. Prevention of keshans disease health conditions vital. Eat foods rich in selenium people who ensure they have a diet that includes foods rich in selenium have protection against developing keshan s disease and have very little risk for this condition. Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Keshan disease is an inflammation of the heart muscle that causes a hearth illness known as cardiomyopathy. Advertisement it has also been suggested that keshan s disease may be, at least partly due to infection by a virus coxsackievirus b3 cvb30, which would initially present with the typical viral infection symptoms such as. Tibet currently has the highest incidence rate of kbd in china.
A fatal heart disease first reported in keshan county of the greater metropolitan qiqihar of the heilongjiang province, mainland china, which affects children and young women. It is found in the soil and in marine bivalves such as oysters. If keshan s disease is not diagnosed and treated, then it can result in heart failure due to the selenium deficiency. Keshan disease selenium for treatment of keshan disease. Which of the following fruits is likely to be the best source of vitamin a.
Some pdf files are protected by digital rights management. Gb170192010control criteria for keshan disease areas text of document is in chinese. It was first observed in keshan province in china, and it has since been found in other areas where the selenium level in. Acquire, and quickly rehabilitate if necessary a motel or hotel building to expand capacity of hospitals to accommodate isolation of patients during recovery. Selenium is an antioxidant in the enzyme seleniumglutathione peroxidase. Selenium, which is nutritionally essential for humans, is a constituent of more than two dozen selenoproteins that play critical roles in reproduction, thyroid hormone metabolism, dna synthesis, and protection from oxidative damage and infection. These symptoms were found prevalent in a wide belt extending from northeast to southwest china, all due to seleniumdeficient soil. Keshan disease is a cardiomyopathy characterized by necrotic lesions throughout the myocardium with varying degrees of cellular infiltration and calcification 7. Dec 04, 2018 home medterms medical dictionary az list disease, keshan definition medical definition of disease, keshan medical author.
Keshan disease and mitochondrial cardiomyopathy springerlink. Apr 08, 2020 keshan disease kd is a lifethreatening condition that affects the heart muscle. Keshan disease, selenium deficiency, and the selenoproteome. Chromium appears to play a role in certain kinds of diabetes and may also be involved in the develop ment of heart disease. Is selenium deficiency really the cause of keshan disease. Keshans disease keshans disease heart gets bigger to increase surface area to catch selenium, pushes ribs out creating barrel chest, only found in china. An endemic osteochondral disease, kashinbeck disease kbd, is widely found in the diagonal southernwest to northerneast zone in china and north korea and in the eastern siberia of russia. Keshan disease genetic and rare diseases information center. Keshan disease herbal treatment, prevention, symptoms. Keshan disease genetic and rare diseases information. The gene expression profiles of kashinbeck and keshan diseases occurring within the same endemic areas of china were compared 66.
Preliminary quantitative proteomics analysis in chronic and latent. Selenium is a trace element that is naturally present in many foods, added to others, and available as a dietary supplement. Selen, a choroby ukladu sercowonaczyniowego wybrane. Keshan disease keshan disease, a cardiomyopathy that occurs almost exclusively in children, is the only human disease that is firmly linked to selenium deficiency keshan disease research group, 1979. Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of coxsackievirus, named after keshan county of heilongjiang province, northeast china, where symptoms were first noted. A condition caused by deficiency of the essential mineral selenium. Pdf files for printing pdf file size approximate download time over a 56k modem. Disease fmd is a contagious disease of clovenhoofed animals. Deficiency can cause a rare heart disorder known as keshan disease. Click on the link to view a sample search on this topic.
Component of the hormone thyroxine produced by the thyroid gland. Kashinbeck disease, which occurs primarily in children. Make interim improvements to private properties to enable an individual patient to. If you have problems viewing pdf files, download the latest version of adobe reader for language access assistance, contact the ncats public information officer genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Southeast siberia and north korea are other affected areas. It is caused by a selenium deficiency and is characterized by pulmonary edema and heart failure. Supplying people living in keshan disease endemic areas with selenium can prevent the disease. An eight month old male infant with protein energy malnutrition was admitted in the hospital with the history of repeated attacks of convulsion since four months of age. These symptoms were later found prevalent in young women and children in a wide belt extending from northeast to southwest china, a region with a seleniumdeficient soil. Two diseases, keshan disease and kashinbeck disease have been reported in humans in seleniumdeficient populations in china. As one of several types of nutritional diseases, keshan disease is unique in that it primarily affects young women and children.
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